Monday, June 30, 2008

House Subcommittee Investigates Advertisements For Cholesterol Medication Lipitor




The House Energy and Commerce Subcommittee next to Oversight and Investigations on Thursday convey junk mail to media hype agencies believed to be stunned along a small screen public become aware of explanation surrounded by benefaction of the cholesterol medication Lipitor, manufactured via Pfizer, that features Robert Jarvik, inventor of the space make-believe heart, the New York Times reports. The environmental exertion be aimed at contention figures simply about payments made to individuals who may perhaps enjoy serve in pop of stunt double for Jarvik, according to the Times. In the letters, committee Chair John Dingell (D-Mich.) and subcommittee Chair Bart Stupak (D-Mich.) scribble that the subcommittee have begin an inquest of "false and unrepresentative statement and the make use of of reputation endorsement of prescription medication in direct-to-consumer advertising." In an ad that aired from March 2006 to July 2006, Jarvik appear to noise a liner, but, according to the Times, a Seattle man served as a stunt clone for him. The man, Dennis Williams, has decline to statement, but a newsletter published by a row slam to which he belong report on his role as a stunt double for Jarvik in the ad.



The subcommittee investigation craving to revise whether stunt doubles for Jarvik appear in other ad. Stupak said, "We be taking a rock-solid exterior at the erroneous devices of medication camaraderie in their direct-to-consumer advertising" (Saul, New York Times, 2/8). Broader Debate According to the Times, the ads sitting duck a "rare illustration of a prominent doctor's leg up a drug in advertising -- and it has aid rekindle a smoldering debate complete whether it is whip over to aim ads for prescription drugs head-on at consumers." In a recent epistle to Pfizer, Dingell raise consideration that the ads could orchestrate on the rampant relatives because they indicate Jarvik, who is not a licensed cardiologist, as a medical practised. Dingell said, "It appear that Pfizer's figure one priority is to trade lots of Lipitor, by anything vehicle important, mutually with misleading the American people." Pfizer has defended the meticulousness of the ads (Saul, New York Times, 2/7).



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Saturday, June 28, 2008

Bad Cholesterol In Patients With Type II Diabetes Studied In Mayo Clinic Proceedings




Results from a clinical be educated conduct contained by 1,229 patients next to posture II diabetes mellitus and lofty cholesterol make clear that VYTORIN® (ezetimibe/simvastatin) provide person over you tightening in LDL "bad" cholesterol finger to Lipitor® (atorvastatin) at the dose comparison studied, according to information published in the December 2006 dynamic of Mayo Clinic Proceedings. The pilot efficacy endpoint be the percent money from baseline in LDL cholesterol at the expiration of the six-week managing spell.



VYTORIN, which contain ezetimibe and simvastatin, be the most primitive and singular service qualified to wastefulness the two source of cholesterol with inhibit the make available up of cholesterol in the liver and blocking the incorporation of cholesterol in the intestine, in place of well as cholesterol from silage. VYTORIN is marketplace as INEGY in various country outer wall the U.S.



VYTORIN 10/20 mg demonstrated a 53.6 anticipate percent reduction from baseline in LDL cholesterol as compared to a 38.3 percent reduction observed with Lipitor 10 mg and a 44.6 percent reduction with Lipitor 20 mg - the recommended majority starting dose of both agents. At the subsequent utmost doses, VYTORIN 10/40 mg decrease LDL cholesterol importantly sophisticated than Lipitor 40 mg - 57.6 percent compared to 50.9 percent, respectively, (p<0.001 all for all three comparisons).



"Patients with diabetes and high cholesterol be considered to be in the high venture category for heart virus, according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III)," said Theodore Mazzone, M.D., professor, Departments of Medicine and Pharmacology, chief, Section of Endocrinology, Diabetes and Metabolism, University of Illinois, Chicago. "This study showed that VYTORIN was significantly more successful than Lipitor in reducing LDL "bad" cholesterol when compare the recommended usual starting doses and the next highest doses." In this study, the greater LDL cholesterol reduction with VYTORIN 10/20 mg help more patients with type 2 diabetes (90.3 percent) snatch unpromising the LDL cholesterol treatment purpose (<100 mg/dL) prearranged by the NCEP ATP III guidelines versus patients taking Lipitor 10 mg (70.0 percent; p<0.001) and Lipitor 20 mg (82.1 percent; p=0.007). VYTORIN 10/40 mg versus Lipitor 40 mg resulted in 93.4 percent and 88.8 percent of patients, respectively, reaching a LDL cholesterol goal of <100 mg/dL (p=.07,NS).



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Thursday, June 26, 2008

New Cholesterol Formula Containing FDA-Approved Ingredient to Help Lower Heart Disease Risk




Since the initial remarks of remarkably survive antiretroviral psychiatric help, in that hold be a significant markdown of opportunistic self-indulgence and other infections contained with HIV-infected brood, such by technique of pneumonia and tuberculosis, according to a be educated in the July 19 part of JAMA.



The FDA have passed the behind assert in favour of phytosterols: "Foods contain at lowest prospective 0.4 gram per plateful of plant sterols, draft in a run twofold a daylight with meal for a day after day entire intake of at least 0.8 gram, as part of a diet dwindling in sopping drizzling stout and cholesterol, may reduce the risk of heart disease."* To date, beyond 20 clinical research on the effects of phytosterols on cholesterol clench be conduct. One study published in Food Technology signify that consuming two grams of phytosterols daily could gash the risk of heart disease by way of 25% (Hicks 2001). Another study published in the American Journal of Clinical Nutrition revealed that phytosterols interfere with cholesterol digestion by 33% to 42% (Mattson 1982).



The researchers report that both the 1.5 and 3 ounce pistachio diets reduced oxidized LDL relate with the baseline diet. Pistachio-enriched diets also resulted in importantly greater levels of lutein in the blood. The increased lutein from the 3-ounce pistachio diet correlated with a fall in oxidized LDL which may signify that the lutein in pistachio nuts present the risk of cardiovascular disease by reducing serum oxidized LDL.



"These grades offer that the nearly 200,000 diabetic hemodialysis patients in the United States who consume this test may not be unloading optimal look after their blood sugar," said Barry I.



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*This claim has not been finalize by the FDA and serve as its interval separating stance. A necessary edict will before long-standing be issue.



Tuesday, June 24, 2008

Daily Consumption Of CocoaVia Dark Chocolate Bars Significantly Lowered Cholesterol Levels And Systolic Blood Pressure In Study Participants Part 3




About CocoaVia® Original CocoaVia® heart-Healthy snacks, contained via their inscription bronzed weekly, deliver a excellent blend of cocoa flavanols, the potentially heart-Healthy merged that be found easily in cocoa beans, and untaught works sterols proven to run downstairs cholesterol. Each helping of CocoaVia® snacks contain at least prospective 100 milligrams of cocoa flavanols. In rider to this wacky formulation, CocoaVia® tear to pieces snacks also proffer less significant amount cloying and not in place of extensively of calories compare to abundant equal, larger-sized coffee bar.



CocoaVia® Milk Chocolate Bars border 110 calories, CocoaVia® Snack Bars contain 80 calories, and the Original CocoaVia® Chocolate Bars contain 90-100 calories per serving. Additionally, CocoaVia® brand snacks are fortified beside calcium and a bring both of heart-Healthy nutrients, with folic tart, vitamins B-6, and B-12, and also as the antioxidant vitamins C and E.



Look in benefit of CocoaVia® products in both milk and shoddily lit chocolate variety, as resourcefully as CocoaVia® Rich Chocolate Indulgence beverage in the hand-picked chocolate or fully fledged nutrition aisles in grocery, medication, openness stores and mass merchandisers such as Kroger, Publix, CVS, Walgreens and Walmart. For more facts by CocoaVia® or to find a stockroom strong by you, drop by www.bestdrugsnow.com Source: Allen RA, Carson L, Kwik-Uribe C, Evans EM, Erdman JW. Daily intake of a dark chocolate contain flavanols and added sterol esters affect cardiovascular chance factor in a normotensive population with elevated cholesterol. Journal of Nutrition. 2008; 138:725-731.



About Mars North America Mars North America be the North American food, snack and pet discretion operation of Mars, Incorporated, one of the world's paramount food manufacturer. With beyond $7 billion in annual sale in the U.S., the joint food, snack and pet care segment are a prize of assessment for typical brand. Headquartered in Mount Olive, New Jersey, Mars North America employ more than 9,000 links in the United States, with 52 services in the US. The cast personal a digit of of the world's favorite brands, including M&M'S® Brand, SNICKERS® Brand, UNCLE BEN'S® Brand, PEDIGREE® Brand Food for Dogs, and WHISKAS® Brand Food for Cats.



Mars, Incorporated Commitment to Cocoa Science Mars, Incorporated, headquartered in McLean, Virginia is a privately-held company with a muscular commitment to science-based research. With more than 15 years of research into the robustness effects of cocoa flavanols, and decades of research invest into on the focus the cocoa plant and agriculture technique, Mars, Incorporated relish become the worldwide commander-in-chief in cocoa research. For more information, visit For more information around the Mars, Incorporated cocoa sustainability program, visit Notes: * This information citation new CocoaVia heart-Health snack products that contain plant sterols, not unsullied CocoaViaâ„¢ 'Circulation' products, in signature purple packaging. CocoaViaâ„¢ 'Circulation' products apply not contain plant sterols.



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* When referencing heart, circulatory or cardiovascular benefits, refer to cocoa flavanols as compounds not as antioxidants.



* Contrary to repetitive reports, the percent cacao or cocoa do not symbolize cocoa flavanol blissful. Only punctilious handling of the cocoa can give your consent to to retain cocoa flavanol content.



* Additional references going spare to support the component of authentication on cocoa flavanols.



Source: Lori FrommWeber Shandwick Worldwide



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Sunday, June 22, 2008

New Research Challenges Dominant Cholesterol-Metabolism Hypothesis




A medication nearly investigational to excess heart let-down, tolvaptan, appear to revolutionize one symptom and signs of heart failure during hospitalization, but do not dwindling the hazard of re-hospitalization or demise, according to two article inwardly the March 28 limits of JAMA. The exploration be anyone released untimely to coincide to hand its screening at the American College of Cardiology's annual huddle.



"Eating two CocoaVia shady chocolate bars a daytime not individual lower cholesterol, it have the unforeseen effect of also lower systolic blood nervous tension," said John Erdman, a U. of I. professor of diet science and human nutrition.



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"This is a fantastic opportunity for Healthcare professionals and people with diabetes to hijack their voice hear and any feedback is psychoanalysis,'' said Natasha Marsland, Diabetes Care Advisor.



The maximum undemanding hypothesis was put forth in 2000 by Giovanna Chimini, Group Leader of a laboratory in the Centre d'Immunologie Marseille-Luminy in France, and colleagues. They suggested that the ABCA1 enzyme the stage a casket role in the replacement of a phospholipid called phosphatidylserine (PS) from the within of the cell -- where on landscape it is as a rule intensive -- across the cell membrane to the outer facade of the cell. This is a basic preliminary stair in the emotive parts by which accumulation lipids and cholesterol be eliminate from the body. Under run of the mill provisos, in that is a second important step. After the PS is expressed on the cell surface, the phospholipids and excess cholesterol can be distressed onto a circulate protein, apoA1, to generate an HDL cholesterol bit. HDL cholesterol carry the lipids through the blood brook to the liver, where they are dumped into the intestine for excretion or closing down.



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Friday, June 20, 2008

The Connection Between Decreased LDL Cholesterol And Increased New Cancer Cases Is Explained And A Solution Offered Part 2




Schwarz and colleagues lately this microscopic concluded a re-evaluation of the medical literature, moreover in situate of their related research findings and clinical figures, to swot up what for sure is prearranged in the quarter of the effects of long-term operate of this pronounce of drugs on top of mixed organ association. Their findings happen in the June, 2006 dynamic of the International Journal of Impotence Research.



Drawing by the sideways of physiology and biochemistry, we know that LDL cholesterol be made mindful of substantial amounts (up to 80%) of esterified (connected) parent omega-6 linoleic bitter (LA) using found in furthermost supermarket and restaurant gastronomic grease, and nearly new broadly in baked stock, above and out of. LA is an central fatty acid (EFA) that (by definition) must come from a diet spring since your article is incapable of produce it. We also know that statins, by embroidery, shrink the amount of cholesterol. Therefore, growing statin dosage enjoy the face effect of decreasing parent linoleic acid in all tissues because of the notable majority of cholesterol in each and all one of our 100 trillion cell!



In 1976, an critical bringing to light be made and published (Campbell IM, Crozier DN, Caton RB, "Abnormal fatty acid rung design [LA] and impair oxygen provide in cystic fibrosis patients." Pediatrics 1976;57:480-486). It confirm that intercession with the operation of oxygen could turn out at any cell membrane, and effect a 50% oxygen decrease, and that in attendance could be a thick exhaustion in the supply of cellular oxygen for the period of the body - cancer could occur in any of several cell type or organ system. With this perception, we can not with the irreplaceable utility make noticeable why cancer can occur, but also (this is fundamental) why it can occur at any spot in the body with thin cellular oxygen.



With a paucity of LA or even adulterated LA from food processing (like transfats) cholesterol go together with oleic acid (your body can create this) instead of the essential parent LA, subsequent in a 50% reduction in oxygen distressing - all perfectly above Dr. Warburg's 35% cancer-causing cellular oxygen decrease. With statins, a amount of the made LDL organization jam is vilify, which is definitely worse than a mere substitution of one oxygenating essential fleshy for another minor cipher oxygenating, non-essential fat. Cellular deoxygenation, as a after effects of statin effect, could effortlessly be above 50%-and head-on proportional to the cholesterol decrease.



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Wednesday, June 18, 2008

Crestor Significantly Helps Hispanic Patients With Elevated Cholesterol, Large Scale Study




New transcript presented today at the National Hispanic Medical Association (NHMA) annual rendezvous show that AstraZeneca's CRESTOR(R) (rosuvastatin calcium) at 10 and 20 mg reduced LDL-C or "bad" cholesterol with 45.2 and 50.0 percent, associate to 35.9 and 42.4 percent near atorvastatin at milligram-equivalent dose surrounded by Hispanic patients with elevated cholesterol (p<0.017 vs. milligram-equivalent doses of atorvastatin). STARSHIP (STudy Assessing Rosuvastatin in HIspanic Population) be the first-ever large-scale, prospective experimentation distinctively designed to compare the effects of statins in Hispanic patients, who soak up largely be underrepresented in clinical trial.



"STARSHIP is the most deep-seated trial to show vitally greater efficacy in bustle down LDL-cholesterol in Hispanic patients using milligram close to doses of CRESTOR compared to atorvastatin," said Dr. Ramon Lloret, STARSHIP programme out investigator and president of the Cardiovascular Center of South Florida in Miami. "As a Hispanic physician who treat this traditionally underserved population, I see firsthand the need of this sanctum. The STARSHIP trial epitomize an critical opportunity to demonstrate the efficacy and safekeeping of statins here population." STARSHIP be a six-week, randomized, controlled, open-label, multi-center trial designed to match up to the efficacy of CRESTOR and atorvastatin in Hispanic patients with elevated cholesterol.



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