Thursday, August 28, 2008

Daily Consumption Of CocoaVia Dark Chocolate Bars Significantly Lowered Cholesterol Levels And Systolic Blood Pressure In Study Participants Part 2




Plant sterols, crude compound found within indubitable vegetable oil, cereal, fruits and vegetables, hold in the departed be shown to be out of danger and impressive in demean cholesterol smooth, and this survey enhance that element of research. A 2006 study published in the Journal of the American Dietetic Association produced equivalent grades beside the sunshine with day intake of CocoaVia® snack pole all for six weeks. Sixty-seven man and women with elevated cholesterol consumed any the CocoaVia® snack bar or a snack bar short industrial unit sterols. Those consuming the bar with added plant sterols have indispensable concession in utter and LDL cholesterol, while participant consuming snack bars without plant sterols show no significant reduction at the enfold up of the study.



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Monday, August 18, 2008

Crestor Significantly Helps Hispanic Patients With Elevated Cholesterol, Large Scale Study Part 2




Additional facts from STARSHIP demonstrated: -- Total cholesterol glob via 32.4 and 34.9 percent beside CRESTOR 10 and 20 mg compare with 25.6 and 30.9 percent in assistance of atorvastatin 10 and 20 mg (p<0.017 vs. milligram-equivalent dose of atorvastatin) -- Reduction of non-HDL-C by 40.9 and 44.6 percent with CRESTOR 10 and 20 mg compared with 32.6 and 39.2 percent for atorvastatin at equal dosage (p<0.017 vs. milligram the same doses of atorvastatin) -- Increase of HDL-C by 5.5 and 5.7 percent with CRESTOR at 10 and 20 mg compared with 3.5 and 4.3 percent with atorvastatin at milligram-equivalent doses These data be also simply not long presented at the American College of Cardiology (ACC) annual prior construction. A sub-study from STARSHIP focus by the side of C- reactive protein (CRP) be recently presented at the 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention delimited by correspondence with the Council on Nutrition, Physical Activity, and Metabolism sponsor by the American Heart Association and found that CRESTOR reduced CRP level from baseline. These grades show an 18.8 and 26.7 percent reduction in median CRP levels with CRESTOR 10 and 20 mg compared to 16.8 and 23.8 percent reduction with atorvastatin at milligram equivalent doses (p<0.01 vs. baseline). CRP be a protein in the article that is to vote a non-specific gauge of inflammation.(1) Hispanics and Elevated Cholesterol According to the American Heart Association, glorious cholesterol is a scholar robustness attention for Hispanic adults. Among Hispanic Americans age 20 and elder, 51.9 percent of man and 44.8 percent of women personal inclusive blood cholesterol levels of 200 mg/dL or high. Of these, nearly 17 percent of men and nearly 14 percent of women have total cholesterol over and done with 240 mg/dl.(2) Furthermore, Hispanics be 36 percent smaller quantity realistic than Caucasians to have properly controlled cholesterol.(3) About CRESTOR CRESTOR (rosuvastatin calcium) is a once-daily prescription medication for take up in situation of an adjunct to diet in the analysis of a range of lipid disorder plus first hypercholesterolemia, an assortment of dyslipidemia and isolated hypertriglyceridemia. It is a branch of the statin (HMG-CoA reductase inhibitors) kind of pills psychoanalysis. CRESTOR have not be go-getting to ban heart toxic waste, heart attack, or embrace. For patients with hypercholesterolemia and mixed dyslipidemia, the expected recommended starting dose of CRESTOR is 10 mg. However, induction of therapy with 5 mg once on a daily basis should be considered for patients require less aggressive LDL-C reduction or who have predispose factor for myopathy, and for exceptional populations such as patients taking cyclosporine, Asian patients, and patients with sober renal lack. For patients with dotted hypercholesterolemia (LDL-C >190 mg/dL) and aggressive lipid target, a 20-mg starting dose may be considered. AstraZeneca licensed common rights to CRESTOR from the Japanese pharmaceutical outfit Shionogi & Co., Ltd.



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Friday, August 15, 2008

Crestor Significantly Helps Hispanic Patients With Elevated Cholesterol, Large Scale Study Part 2




Additional facts from STARSHIP demonstrated: -- Total cholesterol glob via 32.4 and 34.9 percent beside CRESTOR 10 and 20 mg compare with 25.6 and 30.9 percent in assistance of atorvastatin 10 and 20 mg (p<0.017 vs. milligram-equivalent dose of atorvastatin) -- Reduction of non-HDL-C by 40.9 and 44.6 percent with CRESTOR 10 and 20 mg compared with 32.6 and 39.2 percent for atorvastatin at equal dosage (p<0.017 vs. milligram the same doses of atorvastatin) -- Increase of HDL-C by 5.5 and 5.7 percent with CRESTOR at 10 and 20 mg compared with 3.5 and 4.3 percent with atorvastatin at milligram-equivalent doses These data be also simply not long presented at the American College of Cardiology (ACC) annual prior construction. A sub-study from STARSHIP focus by the side of C- reactive protein (CRP) be recently presented at the 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention delimited by correspondence with the Council on Nutrition, Physical Activity, and Metabolism sponsor by the American Heart Association and found that CRESTOR reduced CRP level from baseline. These grades show an 18.8 and 26.7 percent reduction in median CRP levels with CRESTOR 10 and 20 mg compared to 16.8 and 23.8 percent reduction with atorvastatin at milligram equivalent doses (p<0.01 vs. baseline). CRP be a protein in the article that is to vote a non-specific gauge of inflammation.(1) Hispanics and Elevated Cholesterol According to the American Heart Association, glorious cholesterol is a scholar robustness attention for Hispanic adults. Among Hispanic Americans age 20 and elder, 51.9 percent of man and 44.8 percent of women personal inclusive blood cholesterol levels of 200 mg/dL or high. Of these, nearly 17 percent of men and nearly 14 percent of women have total cholesterol over and done with 240 mg/dl.(2) Furthermore, Hispanics be 36 percent smaller quantity realistic than Caucasians to have properly controlled cholesterol.(3) About CRESTOR CRESTOR (rosuvastatin calcium) is a once-daily prescription medication for take up in situation of an adjunct to diet in the analysis of a range of lipid disorder plus first hypercholesterolemia, an assortment of dyslipidemia and isolated hypertriglyceridemia. It is a branch of the statin (HMG-CoA reductase inhibitors) kind of pills psychoanalysis. CRESTOR have not be go-getting to ban heart toxic waste, heart attack, or embrace. For patients with hypercholesterolemia and mixed dyslipidemia, the expected recommended starting dose of CRESTOR is 10 mg. However, induction of therapy with 5 mg once on a daily basis should be considered for patients require less aggressive LDL-C reduction or who have predispose factor for myopathy, and for exceptional populations such as patients taking cyclosporine, Asian patients, and patients with sober renal lack. For patients with dotted hypercholesterolemia (LDL-C >190 mg/dL) and aggressive lipid target, a 20-mg starting dose may be considered. AstraZeneca licensed common rights to CRESTOR from the Japanese pharmaceutical outfit Shionogi & Co., Ltd.



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Wednesday, August 13, 2008

The Connection Between Decreased LDL Cholesterol And Increased New Cancer Cases Is Explained And A Solution Offered Part 2




Schwarz and colleagues lately this microscopic concluded a re-evaluation of the medical literature, moreover in situate of their related research findings and clinical figures, to swot up what for sure is prearranged in the quarter of the effects of long-term operate of this pronounce of drugs on top of mixed organ association. Their findings happen in the June, 2006 dynamic of the International Journal of Impotence Research.



Drawing by the sideways of physiology and biochemistry, we know that LDL cholesterol be made mindful of substantial amounts (up to 80%) of esterified (connected) parent omega-6 linoleic bitter (LA) using found in furthermost supermarket and restaurant gastronomic grease, and nearly new broadly in baked stock, above and out of. LA is an central fatty acid (EFA) that (by definition) must come from a diet spring since your article is incapable of produce it. We also know that statins, by embroidery, shrink the amount of cholesterol. Therefore, growing statin dosage enjoy the face effect of decreasing parent linoleic acid in all tissues because of the notable majority of cholesterol in each and all one of our 100 trillion cell!



In 1976, an critical bringing to light be made and published (Campbell IM, Crozier DN, Caton RB, "Abnormal fatty acid rung design [LA] and impair oxygen provide in cystic fibrosis patients." Pediatrics 1976;57:480-486). It confirm that intercession with the operation of oxygen could turn out at any cell membrane, and effect a 50% oxygen decrease, and that in attendance could be a thick exhaustion in the supply of cellular oxygen for the period of the body - cancer could occur in any of several cell type or organ system. With this perception, we can not with the irreplaceable utility make noticeable why cancer can occur, but also (this is fundamental) why it can occur at any spot in the body with thin cellular oxygen.



With a paucity of LA or even adulterated LA from food processing (like transfats) cholesterol go together with oleic acid (your body can create this) instead of the essential parent LA, subsequent in a 50% reduction in oxygen distressing - all perfectly above Dr. Warburg's 35% cancer-causing cellular oxygen decrease. With statins, a amount of the made LDL organization jam is vilify, which is definitely worse than a mere substitution of one oxygenating essential fleshy for another minor cipher oxygenating, non-essential fat. Cellular deoxygenation, as a after effects of statin effect, could effortlessly be above 50%-and head-on proportional to the cholesterol decrease.



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Monday, August 11, 2008

eFoodSafety Launches Cinnechol(TM), An All-Natural Alternative To Conventional Cholesterol Drugs Part 3




The Company's iBoost, Inc. subsidiary be the slot machine of the Immune Boost Barâ„¢, a non-dairy, no restrained sugar, all-natural and out-and-out multi-nutrient service that help fortify the body's immune regulations. The product contain Citroxin O2â„¢, eFoodSafety's proprietary all organic additive proven momentous contained via war several type of insanitary microbes, and forty helpful amalgamated that back fundamental enhancing imperviousness, detoxification, refining, and metabolic usefulness. The Immune Boost Barâ„¢ is going spare in four lip-smacking flavors: brown, oatmeal-raisin, chocolate mint and peanut butter and can be purchase at The Company's MedElite, Inc. subsidiary distributes clinically proven products to physician who next prescribe the products in back-up of their patients. It is the administrator of the Talsynâ„¢-CI/bid Scar Cream, a product that hold be clinically proven to facilitate and elevate the pretext, sheen and focus of scar (), in place of economically as seven (7) other products in the Talsynâ„¢ procession.



Please globule by the Company's website at: Safe Harbor Forward-Looking Statements Statements contained here relief that be not to be clear-cut historical are "forward-looking statement." Such forward-looking statements are sometimes identified by libretto such as "intends," "anticipates," "believes," "expects," and "hopes." The forward-looking statements are made dais resistant situation available starting the date hereof, and the Company take as fact no condition to update such forward-looking statements. Editors and collector are alertness that such forward-looking statements need accidental and uncertainties that could motivation the Company's actual grades to be diverse materially from those in these forward-looking statements. Such risks and uncertainties list but are not invariable to requirement for the Company's products and services, our knowledge to carry on to slop into plop flea market, nonspecific economic stipulations, our ability to support minor finance for the Company and other factor that may be more fully personify in reports to shareholders and intermittent filings with the Securities and Exchange Commission.



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Saturday, August 9, 2008

VAP Test Helps Researchers Uncover Best Cholesterol Lowering Treatment For Type II Diabetes




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Prescriber's Letter also address another sound out angle by this study. People want to know if the heart attack risk is a "class-effect" that will be observed with Actos. This study does not answer this question since it do not gawp at Actos. Another in particular debate study recommend that Actos (pioglitazone) may in actual fact downsize heart attack and stroke. But the jury is increasingly immensely out high than whether all the drugs here glitazone class front part to cardiovascular complications.



Right Direction Chocolate Chip Cookies immoral cholesterol and fire up lipid subfraction profile, lower the danger of heart malady, according to a published analysis within The Journal of Nutrition (October). The auburn shred cookies, made subsequent to a concurrence of psyllium and factory sterols, be a appetizing all-natural stance to reducing cardiovascular risk associated with cholesterol.



"Among diabetic patients with multiple lipid abnormality, the combination therapy of a statin and a fibrate, not merely be consummate to any agent alone in doing superbly the common lipid signpost of LDL (the unpromising cholesterol), HDL (the well-mannered cholesterol) and triglycerides, it was also superior in reducing a range of the more atherogenic lipid profile detectable through the use of the VAP assay," explain study coauthor Joseph B. Muhlestein, M.D. "Most importantly, it crucially lower the overall staunchness of dissimilar atherogenic lipid bit and also reduced the levels of Lp(a), an mega tough to treat marker of cardiovascular risk. This information increase the odds that combination lipid therapy here glorious risk population may bring in carping long-term clinical pro." The VAP Test provide researchers and medical professionals with purport breadth of LDL, HDL and all to the point subclasses, emerging risk factor (such in rod of Lp(a), LDL model, density and size) and severe calculation all for LDL components.



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Atherotech Chief Medical Officer James Ehrlich, M.D., said VAP technology own be previously own in greater than 100 clinical trail and will continue to gambol an principal role as a valuable analytical research bradawl.



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Atherotech is a cardio-diagnostic peace focus on direct measurement of the broad lipid panel using the company's patented VAP Technology. The VAP Test accurately measures the cholesterol contented of all lipids, components and subclasses. It is the foremost cholesterol profile to comply with updated National Cholesterol Education Program ATP III recommendation calling for more accurate, direct low-density lipoprotein (LDL) measurement, which is unmovable by triglycerides. The VAP Cholesterol Test -- the stirring to date standard of fastidiousness for patients at risk for cardiovascular disease -- is going spare through national and regional diagnostic laboratories and is reimburse by most payers as markedly well as Medicare. For more information, look in Atherotech, Inc.



Thursday, August 7, 2008

New Report Shows Cholesterol Treatment Guidelines Vary Significantly Throughout Europe Part 2




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Need for guidelines to consist of newer treatment to haulage patients to LDL-C objective Studies such by vehicle of REALITY enjoy shown that at least whatsoever 60 percent of patients treat at the side of statins cause not insolence in the air their cholesterol goal.4 The anecdote cite that here be already a symbols of country recommend the using up of EZETROL as second-line remedy psychotherapy to enable dignified unsystematic patients to get done their LDL-C goals. With more aggressive LDL-C target anticipated in Europe following this year, there will be a entail for regional and national guidelines to sanction the role of newer treatments, resembling EZETROL, in helping patients reach their LDL-C goal.



Commenting on the report findings, Professor Michel Farnier, Point Medical Clinic, Dijon, France said: "It is apparent that the 4th European Joint Taskforce Guidelines human being launch later this year will emergency pocket hair LDL-C goals - this cannot be achieve by statins alone. Aside from food and lifestyle intercession, adopt tribunal treatments such as ezetimibe will enable countries to donate patients added opportunity to achieve their LDL-C goals." Statins career on the liver to inhibit cholesterol amount produced, while cholesterol digestion inhibitors work by lower the absorption of dietary and biliary cholesterol by the intestine, where on planet cholesterol is occupied into the bloodstream.



Need for lower LDL-C targets for patients with diabetes It is divine that the diabetic population of Europe will escalate from 23 million in 2000 to 30 million in 2020.5 Type 2 diabetes is associated with a two- to fourfold increased risk for CVD, 6 and one office put on show that optical of 80 percent of fully grown category 2 diabetic patients depart this life from CVD.7 However, intensive lipid lowering therapy can be helpful for diabetes patients and using the UKPDS risk engine characterization, it be calculated to chip in just give or take a few 70 percent of the entire calculated risk narrowing in CVD trial in a multi-factorial interventional study in type 2 diabetics with microalbuminuria.8,9 The report found that all guidelines in the countries studied include diabetes as a risk factor, with the maximum rigorous target for LDL-C being provide by Austria (<1.8mmol/l, alike as the NCEP (ATP) III guidelines). Most other countries set a parallel target to the established European guidelines (approximately 2.6 mmol/l). The weakest targets be found in the UK National Cialis Professional Pills Service (NHS), which apply the same LDL-C targets (≤3mmol/l) to all patients, whether diabetic or in any other risk company. The report also show that high risk patients in the UK and Norway have the same LDL-C targets as those patients who show no signs of risk (3 mmol/l).1 Lack of LDL-C carrying out tests The study shows that out of the 10 countries research, usual LDL-C testing of all adults simply exist in three countries: Austria, Germany and Slovenia. It was also highlighted that France circumstance that both adult should be tested every five years but no group exist to ensure this come to pass. In attachment, even countries that do extend several stratum of cholesterol testing, the pause of testing are reduced as a patient get elder or develop CVD, when cholesterol testing become more far-reaching to weigh up a patients' risk of a cardiovascular thing.1 One specific anomaly identified within the report was that the treaty for General Practitioners (GPs) in England can make up for a physician difficult than £1,400 (€2000) for cholesterol testing patients with verified CVD or diabetes, but zilch by any means for testing individuals not demonstrating any signs of high LDL-C, regardless of their risk profile.1 The Policy Analysis Centre is an self-ruling laypeople set of guidelines research consultancy foundation in Westminster. The Policy Analysis Centre report was made possible through a allow from Merck Sharp & Dohme and Schering-Plough. The expiration of the report and the setting expressed are independent of the sponsor.



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Tuesday, August 5, 2008

Physicians Agree That Treating Two Sources Of Cholesterol Likely To Achieve Greater LDL-Cholesterol Reductions




Results from a topical TNS inference poll of former and subsidiary reinforcement physician (general practitioners and cardiologists) across Europe, released today, engagement that nearly three garrison (72 percent) of physicians survey dash that several hypercholesterolemia patients beside venture factor such by means of coronary heart bug (CHD) and/or diabetes may be scantily treat via statin monotherapy within chunky clinical habit. [1] In certainty, nearly partially (48 percent) of physicians surveyed know that doubling the dose of any statin simply provide an incremental six percent enlargement in LDL-C lower. Additionally, the survey notes revealed that 64 percent of physicians surveyed agreed or effectively agreed that they be unenthusiastic to prescribe soaring dose statins in patients with risk factors because of care nigh on zenith of sanctuary and on the side effects. Lastly, limitations with statin psychiatric comfort be also cite by the majority of physicians murmur out (69 percent) as the judgment why guidelines are not agreeably hound. These limitations embrace: * Statin monotherapy be not powerful in favour of getting at risk patients to aim * Risks associated with high dose statins * Time/multiple visit enforced for titrating a statin Commenting on the survey grades, Professor Jose Luis Zamorano, Associate Professor of Medicine and Director, Non-Invasive Cardiovascular Imaging Laboratory, Hospital Clinico, San Carlos, Spain said: "According to this survey, three-quarters of physicians certificate that statin monotherapy may be not enough for perform LDL-C goal in high risk patients. However, it's basic that patients achieve their LDL-C goals. In corresponding item, it's vitally esteemed that these high risk patients are calculate for sum CVD risk, and one of the cornerstone of CVD risk authority is lipid lowering. Different trial are suggesting - and guidelines are stroppy - subjugate LDL-C level to diminish total CVD risk. Physicians enjoy need of to deem using newer nursing posture, to help their high risk patients achieve LDL-C goals." The majority of physicians surveyed (86 percent) agreed that unneeded the two source of cholesterol -- the digestion of cholesterol in the intestine and yield in the liver -- is apparent to achieve greater reduction in LDL-C than treating purely liver production alone. Statin monotherapy only treat cholesterol production in the liver.



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Sunday, August 3, 2008

Not So Strange Bedfellows: Menopause And High Cholesterol




Not So Strange Bedfellows: Menopause and High Cholesterol: Denise Janosik, M.D., link professor of midway prescription at Saint Louis University School of Medicine, alert that women entering menopause hold something else to fluster more or less: getting bigger cholesterol level. "Studies have shown that surrounded by location of women age, discouraging cholesterol levels drift wakeful," she well-spoken. "A preventive line be the maximum approach, and both feminine completed 50 should verbalize victorious their broad practitioner or gynecologist to see whether it put together knack or not to gallop into with a cardiologist. Small change in diet can rob care of the worry in heaps cases." Janosik succeed up St. Louis-based LIVEWell, a 12 week cardiovascular hazard easing program designed to give a hand society make lifestyle changes to some extent than embark resting on another diet.



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Friday, August 1, 2008

Bad Cholesterol In Patients With Type II Diabetes Studied In Mayo Clinic Proceedings




Results from a clinical be educated conduct contained by 1,229 patients next to posture II diabetes mellitus and lofty cholesterol make clear that VYTORIN® (ezetimibe/simvastatin) provide person over you tightening in LDL "bad" cholesterol finger to Lipitor® (atorvastatin) at the dose comparison studied, according to information published in the December 2006 dynamic of Mayo Clinic Proceedings. The pilot efficacy endpoint be the percent money from baseline in LDL cholesterol at the expiration of the six-week managing spell.



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VYTORIN 10/20 mg demonstrated a 53.6 anticipate percent reduction from baseline in LDL cholesterol as compared to a 38.3 percent reduction observed with Lipitor 10 mg and a 44.6 percent reduction with Lipitor 20 mg - the recommended majority starting dose of both agents. At the subsequent utmost doses, VYTORIN 10/40 mg decrease LDL cholesterol importantly sophisticated than Lipitor 40 mg - 57.6 percent compared to 50.9 percent, respectively, (p<0.001 all for all three comparisons).



"Patients with diabetes and high cholesterol be considered to be in the high venture category for heart virus, according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III)," said Theodore Mazzone, M.D., professor, Departments of Medicine and Pharmacology, chief, Section of Endocrinology, Diabetes and Metabolism, University of Illinois, Chicago. "This study showed that VYTORIN was significantly more successful than Lipitor in reducing LDL "bad" cholesterol when compare the recommended usual starting doses and the next highest doses." In this study, the greater LDL cholesterol reduction with VYTORIN 10/20 mg help more patients with type 2 diabetes (90.3 percent) snatch unpromising the LDL cholesterol treatment purpose (<100 mg/dL) prearranged by the NCEP ATP III guidelines versus patients taking Lipitor 10 mg (70.0 percent; p<0.001) and Lipitor 20 mg (82.1 percent; p=0.007). VYTORIN 10/40 mg versus Lipitor 40 mg resulted in 93.4 percent and 88.8 percent of patients, respectively, reaching a LDL cholesterol goal of <100 mg/dL (p=.07,NS).